Setra 25mg 10pcs

Indications

Sertraline is indicated for the treatment of-

• Panic disorder (PD)
• Post-traumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder (PMDD).
• Major depressive disorder (MDD)
• Obsessive-compulsive disorder (OCD)
• Social anxiety disorder (SAD)

Pharmacology

Sertraline has a potent and specific inhibitory effect on CNS neuronal 5-HT reuptake, resulting in increased 5-HT concentrations at synaptic clefts and aiding in the maintenance of its action at postsynaptic receptor sites. It eventually manifests as a progression of despair. Another factor entangled in its action is sertraline's reduction of serotonin turnover in the brain. Because of its delayed elimination half-life, the once-per-day organization is a benefit.

Dosage & Administration

Adults-
Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:

• Starting Dose: 25 mg
• Therapeutic Range: 50-200 mg

Major depressive disorder:

• Starting Dose: 50 mg
• Therapeutic Range: 50-200 mg

Obsessive-compulsive disorder:

• Starting Dose: 50 mg
• Therapeutic Range: 50-200 mg

Pediatric Patients (ages 6-12 years old)-

Obsessive-compulsive disorder:

• Starting Dose: 25 mg
• Therapeutic Range: 50-200 mg

The recommended interval between dose changes is one week.

Premenstrual dysphoric disorder (PMDD): 

• Starting PMDD medication is 50 mg/day. Sertraline can be given continuously (every day during the menstrual cycle) or sporadically (starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). With each new cycle, intermittent dosing would be repeated.

Continuous: 

• Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.

Intermittent:

• Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles).

Interaction

The administration of Sertraline to a patient who is already taking another medication that is tightly linked to protein, such as warfarin or digitoxin, may produce a change in plasma concentrations that could have an unfavorable effect. This is because Sertraline is tightly bound to plasma proteins. On the other hand, Sertraline which has been protein-bound may be replaced by other medications that are strongly bound, causing negative effects. Other medications like Cimetidine, CNS-active pharmaceuticals like Diazepam, Hypoglycemic medications, Atenolol, etc. may interact with sertraline.

Contraindications

Escitalopram is not recommended for patients who have a known hypersensitivity to Escitalopram, Citalopram, or any of the drug's inactive ingredients. It's not a good idea to take escitalopram and monoamine oxidase/pimozide at the same time.

Side Effects

• Delayed ejaculation
• Erectile dysfunction
• Indigestion
• Insomnia (difficulty in sleeping)
• Low sexual desire
• Nausea
• Tremor
• Diarrhea
• Increased sweating
• Loss of appetite

Pregnancy & Lactation

Although animal studies did not provide any evidence of teratogenicity, the safety of Sertraline during human pregnancy has not been established. Sertraline is known to be excreted in breast milk. Its effects on the nursing infant have not yet been established. If treatment with Sertraline is considered necessary, discontinuation of breastfeeding should be considered.

Precautions & Warnings

In the event of seizures, heart problems, liver problems, kidney problems, or other hypersensitivity, precautions should be taken. The sedative could make you drowsy or lazy. Exercises requiring readiness, such as operating machinery or driving a car, should be done with caution. The elderly should exercise caution when using this product since they may be more sensitive to the side effects of the drug. If you have taken a monoamine oxidase inhibitor within the previous five weeks, avoid using this drug. A chance of developing self-destructive thoughts and changing one's conduct exists (close observation of the understanding after two to three weeks of use is necessary).

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.