Setra 25mg 10pcs

✔️ Uses

• Depression
• Post-traumatic stress disorder
• Obsessive-compulsive disorder
• Panic disorder
• Premenstrual dysphoric disorder
• Anxiety

✔️ Dosage & Administration

Adults-
Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:

• Starting Dose: 25 mg
• Therapeutic Range: 50-200 mg

Major depressive disorder:

• Starting Dose: 50 mg
• Therapeutic Range: 50-200 mg

Obsessive-compulsive disorder:

• Starting Dose: 50 mg
• Therapeutic Range: 50-200 mg

Pediatric Patients (ages 6-12 years old)-

Obsessive-compulsive disorder:

• Starting Dose: 25 mg
• Therapeutic Range: 50-200 mg

The recommended interval between dose changes is one week.

Premenstrual dysphoric disorder (PMDD): 

• The starting PMDD medication is 50 mg/day. Sertraline can be given continuously (every day during the menstrual cycle) or sporadically (starting the daily dosage 14 days before the anticipated onset of menstruation and continuing through the onset of menses). With each new cycle, intermittent dosing would be repeated.

Continuous: 

• Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.

Intermittent:

• Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles).

✔️ Side Effects

• Delayed ejaculation
• Erectile dysfunction
• Indigestion
• Insomnia (difficulty in sleeping)
• Low sexual desire
• Nausea
• Tremor
• Diarrhea
• Increased sweating
• Loss of appetite

✔️ Interaction

Protein Binding Interaction:

• Sertraline is highly protein-bound. Administering it alongside other highly protein-bound medications such as Warfarin or Digitoxin may alter plasma concentrations, leading to unfavorable effects.
• Sertraline's protein-binding capacity can also be affected by other medications, potentially leading to displacement and adverse outcomes.

Drug Interactions:

• Cimetidine: May alter Sertraline metabolism.
• CNS-active drugs (e.g., Diazepam): Increased sedation or CNS effects.
• Hypoglycemic medications: Interaction may affect blood sugar control.
• Atenolol: Possible alteration in cardiovascular response.

✔️ Contraindications

• Escitalopram Contraindications:
  • Not recommended for patients with hypersensitivity to Escitalopram, Citalopram, or any inactive ingredients in the formulation.
  • Contraindicated with monoamine oxidase inhibitors (MAOIs) or Pimozide, as this combination can result in severe drug interactions.

✔️ Pregnancy & Lactation

Pregnancy:

• While animal studies have not shown teratogenicity, the safety of Sertraline during pregnancy in humans has not been established. Use during pregnancy should only occur if the potential benefits justify the potential risks to the fetus.

Lactation:

• Sertraline is excreted in breast milk, and its effects on nursing infants remain unknown. If Sertraline treatment is deemed necessary, discontinuing breastfeeding should be considered.

✔️ Precautions & Warnings

• Use with caution in patients with a history of seizures, cardiovascular problems, hepatic or renal impairment, or other hypersensitivities.
• Sertraline may cause drowsiness or lethargy. Activities requiring alertness, such as operating machinery or driving, should be undertaken cautiously.
• Older adults may be more susceptible to the drug’s side effects, requiring additional monitoring.
• Do not use Sertraline if a monoamine oxidase inhibitor (MAOI) was taken in the previous five weeks, as this could result in serious adverse effects.
• There is a potential risk of self-destructive thoughts and behavioral changes, particularly during the initial 2–3 weeks of therapy. Close monitoring of the patient is essential.

✔️ Storage Conditions

• Store below 30°C, protecting from light and moisture.
• Keep out of reach of children.